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Topics ICP & CARNet Clinical Science Lab

Endogenous circadian rhythm in cerebrovascular reactivity
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Kun Hu, PhD; Director, Medical Biodynamics Program, Brigham & Women's Hospital, Assistant Professor of Medicine, Harvard Medical School, Boston, USA
Aim 1:To determine the influence of the circadian system on cerebrovascular reactivity
Aim 2:To determine the response of cerebrovascular reactivity to bright light during the nighttime
Aim 3:To determine the role of autonomic function in the circadian influence on cerebrovascular reactivity
Accurate Noninvasive ICP using an Individualized Dynamic System Modeling Approach
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Xiao Hu, PhD; Associate Professor of Physiological Nursing and Neurosurgery, Affiliate Member of Institute for Computational Health Science, Affiliate UCB/UCSF Joint Bio-Engineering Graduate Program, University of California, San Francisco, USA
Aim 1:To design and standardize a protocol to develop a signal repository that will at a minimum include concurrently measured invasive ICP, at least one lead of electrocardiogram (ECG), cerebral blood flow velocity (CBFV), and invasive or noninvasive arterial blood pressure (ABP).
Aim 2:To assess the full-potential of a novel noninvasive ICP algorithm using the database.
Aim 3:To advance the state-of-the-art of noninvasive ICP by using this database to fairly benchmark noninvasive ICP methods that are developed at different laboratories.
The changes of cerebral blood flow velocities to follow patients with acute not traumatic brain injury admitted to the intensive care unit – INCN
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Maria Mercedes Chumbe Mendoza, MD; Intensive Care Physician, Emergency Department, National Institute of Neurological Science, Lima, Peru
Aim 1:To identify the individual optimal mean arterial pressure in the acute setting.
Aim 2:To identify the end diastolic velocity (EDV) and the pulsatility index (PI) utility as accessible tools to follow interventions and outcome in non-traumatic brain injured patients.
Cerebral blood flow regulation during and after thrombolysis for acute ischemic stroke: a prospective study
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Ricardo Nogueira, MD; Neurology Department, Hospital das Clínicas, University of Sao Paulo, Sao Paulo, Brazil & Department of Cardiovascular Sciences and NIHR Biomedical Research Unit on Cardiovascular Disease, University of Leicester, Leicester, United Kingdom
Aim 1:Study Cerebral Blood Flow regulation during and after thrombolysis for acute ischemic stroke
Aim 2:Correlate hemodynamic impairment with infarct size and clinical outcome
Aim 3:Evaluate if r-tPA therapy causes impairment of blood flow regulation
Diastolic Closing Margin predicts brain injury in premature infants
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Christopher J. Rhee, MD, MS, FAAP; Baylor College of Medicine, Texas Children's Hospital, Section of Neonatology, Houston, USA
Aim 1:Prospectively determine whether high brain perfusion pressure (i.e., high Diastolic Closing Margin, DCM) is predictive of Intraventricular Hemorrhage (IVH)
Aim 2:Prospectively determine whether low brain perfusion pressure (i.e., low Diastolic Closing Margin, DCM) is predictive of Periventricular Leucomalacia (PVL)
Aim 3:Determine whether physiologic measurements of brain perfusion are predictive of neurodevelopmental outcomes
Validation and combined assessment of non-invasive ICP methods
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Danilo Cardim, MSc, Department of Clinical Neurosciences, Brain Physics Laboratory, University of Cambridge
Aim 1:To design and standardise experimental and clinical protocols for validation of these methods against gold standard techniques.
Aim 2:To compare these methods with other non-invasive ICP methods, such as TCD-based methods.
Aim 3:To assess potential uses of these methods outside neurocritical care environments.
How to decipher the Heart-Brain-Cross-Talk after Traumatic Brain Injury
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Pietro Lió, PhD; Computer Lab, Department of Science, University of Cambridge, United Kingdom
Aim 1:Modeling the transient interaction between Intracranial Pressure and Heart Rate after Traumatic Brain Injury (TBI) in pediatric patients
Aim 2:Machine learning approach to identify patterns and conditions of Heart-Brain-Cross-Talk
Aim 3:Prospective evaluation in order to predicting critical conditions after TBI